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HISTOLOGY ONCOLOGY SIDE EFFECTS
HISTOLOGY
NEURODEGENERATION
STANDARD COLORATION
NEUROFIT offers a computer assisted histological platform to investigate changes in morphological profile of peripheral nerves parameters: axonal area, relative myelin sheath thickness, fiber size distribution, fibers density.
As in clinical peripheral neuropathy, NEUROFIT uses the loss in the density of Intra-Epidermal Nerve Fibers as a sensitive hallmark of peripheral neuropathy.
NEUROFIT routinely performs, as part of a study, dissection of brain microstructures from compound-treated animals (mouse or rat) to provide customers with useful samples for their : pharmacokinetic, biochemistry and immunochemistry analyses.
NEURODEGENERATION INVESTIGATION
ON PERIPHERAL NERVES
STANDARD COLORATION
ON PARAFFIN AND CRYOSECTIONS
Axonal area
G-ratio (relative myelin thickness)
Fiber size distribution
Fiber density
Percentage of degenerated fibers
(manual counting of axonal degeneration)
HE staining
Toluidin blue staining