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NEUROLOGY
 HISTOLOGY ONCOLOGY SIDE EFFECTS
NEUROLOGY NEUROFIT has developed models for several diseases :
These models are used to evaluate the neurotoxic, neuroprotective or neurorestorative effects of drug candidates.
ALZHEIMER'S DISEASE
AMYOTROPHIC LATERAL
SCLEROSIS
EPILEPSY
MOTONEURON DEGENERATION
MULTIPLE SCLEROSIS
PARKINSON'S DISEASE
NEUROPATHY
NEUROTROPHIC EFFECTS
NEUROPROTECTIVE EFFECTS
PAIN (ACUTE / CHRONIC)
ARTHRITIS
STROKE
ALZHEIMER'S DISEASE
AMYOTROPHIC LATERAL
SCLEROSIS
EPILEPSY
In vivo
Object Recognition
Reversal of scopolamine-induced deficits
In vitro
β-Amyloid-induced neurotoxicity in rat hippocampal neurons
In vitro
Excitotoxicity model: inhibition of glutamate or NMDA toxicity in
Cortical neurons
Spinal motor neurons
In vivo
PTZ-induced seizure in mice
MOTONEURON DEGENERATION
MULTIPLE SCLEROSIS
ARTHRITIS
In vitro
Survival and
Morphology of spinal motor neurons
In vivo
RR-EAE model measuring clinical score of paralysis (Newsletter)
Acute EAE model
DTH
In vitro
OPC Proliferation
In vivo
Collagen induced arthristis
Other inflamatory model
Air-Pouch
NEUROPATHY
NEUROTROPHIC EFFECTS
NEUROPROTECTIVE EFFECTS
In vitro
Neurotrophic effects on rodent primary cell cultures:
Dorsal root ganglion neurons (DRG) in dissociated culture
Schwann cell
Cortical neurons
viability rate
neurite outgrowth
Purified spinal motor neurons
viability rate
neurite outgrowth
Rat nerve/human muscle co-culture
Inhibition of vincristin, cisplatin or taxol neurotoxicity on :
sensory neurons
co-culture sensory neurons and Schwann cells
In vivo
Diabetic neuropathy
tail flick, electrophysiology and histology
Diabetic painful neuropathy
in the rat
Sciatic nerve crush
electrophysiology and histology
Mesures of the density of the epidermal nerve fibers in skin biopsies
In vitro
Drug-induced effects on primary cortical, mesencephalic or sensory cell cultures. Measurements can be neurite outgrowth, viability rate or neuron-specific protein markers
Cortical neurons
survival
neurite outgrowth
Hippocampal neurons
Spinal motor neurons
Rat nerve / human muscle co-culture
In vitro
Excitotoxicity model:
Inhibition of glutamate or NMDA toxicity in
Spinal motor neurons
Parkinson's model:
Inhibition of MPP+ toxicity in mesencephalic cells
Purified sensory neurons intoxicated with cisplatin, vincristine or taxol
Sensory neurons and schwann cells coculture intoxicated with cisplatin, vincristine or taxol
PAIN (ACUTE / CHRONIC)
PARKINSON'S DISEASE
STROKE
In vivo
Diabetic painful neuropathy in the rat:
Hot plate
Tail flick
Von Frey filament
Paw pressure (Randall Sellito)
In vitro
Inhibition of MPP+ toxicity in mesencephalic cells
In vivo
Catalepsy
In vitro
Inhibition of glutamate toxicity in cortical neurons