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December NEWSLETTER 2011
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SCHIZOPHRENIA
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Schizophrenia is a chronic, severe and disabling brain disorder that affects about 1% of people over the age of 18 years. Patients diagnosed with schizophrenia usually experience multiple symptoms such as hallucinations, delusional thoughts, apathy, lack of emotion, poor social functioning and cognition disorders. Although there is no cure for schizophrenia, current antipsychotic drug helps relieve the symptoms of schizophrenia, but lifelong treatment is usually required.
Psychotomimetic drugs, such as Phencyclidine (angel dust), produce schizophrenia-like symptoms in humans.
In laboratory animals, they induce locomotor hyperactivity which is a widely used method for the screening of antipsychotic drug candidates.
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Hyperactivity data samples
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HALOPERIDOL / AMPHETAMINE
Travelled distance (cm/5min)
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HALOPERIDOL / AMPHETAMINE
Total travelled distance (cm/60min)
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CLOZAPINE / AMPHETAMINE
Travelled distance (cm/5min)
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CLOZAPINE / AMPHETAMINE
Total travelled distance (cm/60min)
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HALOPERIDOL / MK-801
Travelled distance (cm/5min)
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HALOPERIDOL / MK-801
Total travelled distance (cm/60min)
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CLOZAPINE / PCP
Travelled distance (cm/5min)
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CLOZAPINE / PCP
Total travelled distance (cm/60min)
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Catalepsy data samples
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