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HISTOLOGY ONCOLOGY SIDE EFFECTS
ONCOLOGY
NEUROFIT is pleased to announce the expansion of our services in Oncology :

The inhibition of blood vessel formation (neovascularization) and the disruption of blood vessels within the tumor is one of the most promising therapeutic strategies for treating cancer.
NEUROFIT offers in vitro as well as in vivo preclinical assays to screen new drug candidates for Oncology.
CANCER CELL LINES PROLIFERATION ASSAY
INHIBITION OF BLOOD VESSEL FORMATION / DISRUPTION OF BLOOD VESSELS WITHIN THE TUMOR
In vitro Preclinical Platform
Capillary Formation
on matrigel
Untreated
Drug treated
In vivo Preclinical Platform
Capillary Disruption
0 h
5 h
Calcein
Vehicle
treated
Drug
treated
Vascular Disruption Study:
Qualitative and quantitative measure of blood vessel perfusion in tumors and normal tissues as well as tumor necrosis
Vehicle treated
Drug treated
Xenograft
Xenograft mouse models with single agent efficacy or combination studies. Cancer indications include breast, colon, renal, lung, head & neck, prostate and mesothelioma
Other assays such as Endothelial cell proliferation, permeability and morphology, comprehensive list of cancer cell lines for high-throughput screening, in vivo MTD studies, repeat dosing schedule studies and histological validation of tumor vascularization (CD31, VEGF) are also available.
other ASSAYS
 DESCRIPTION
Capillary Formation
 Assesses the ability of endothelial cells to form capillaries on Matrigel
Capillary Disruption Assesses the ability of compounds to disrupt capillaries on Matr
Endothelial Proliferation Measures the proliferative capacity displayed by endothelial cells
Proliferation Cancer Library Measures the proliferative capacity displayed by cancer cells
Permeability Assesses the ability of compounds to alter the permeability of a endothelial cell monolayer
Morphology Assesses changes in endothelial cell morphology
Vascular Disruption Qualitative & quantitative measure of blood vessel perfusion in tumor and normal tissues
Tumor Xenograft Qualitative & quantitative measure of tumor growth
MTD Maximum tolerated dose studies
DRF Dose range finding study