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NEUROFIT offers an extensive repertoire of validated screening tests in :
NEUROFIT offers a variety of well-accepted behavioral tests to assess the potential anxiolytic, antidepressant or antipsychotic effects as well as cognitive enhancing and disrupting effects on learning and memory.
NEUROFIT has developed models for several diseases such as Parkinson's Disease, Epilepsy, Multiple Sclerosis, Arthritis, Pain, Nerve injury and Peripheral neuropathies ...
NEUROFIT has developed a comprehensive range of rat primary neuronal culture models and assays to evaluate neurotoxicity, neuroprotective or neurotrophic effect of test compounds.
NEUROFIT offers a computer assisted histological platform to investigate changes in morphological profile of peripheral nerves parameters: axonal area, relative myelin sheath thickness, fiber size distribution, fibers density...
NEUROFIT offers an in vitro and in vivo preclinical platform of assays, studies and models for the evaluation of new and novels compounds and therapeutics for cancer.
Cognitive disturbances, motor coordination, sedation ...
Under a Master Services Agreement a program can be established, where you work directly with the scientist responsible for the testing as if this person was working in your own laboratory. This will allow you to rapidly obtain access to already validated screening methods and to draw on our in-house expertise. Data reporting, study performance etc... will of course be adapted to your specific needs during your direct interactions with the responsible scientist.
PHENOMOUSE :
According to your target indications we can establish a screening program for your drug project. In-house expertise allow us to assist you in most CNS and PNS disorders.

PHENOMOUSE consists of phenotyping mutant mice by behavioural, histological and biochemical tests.
A progressive phenotyping is performed in a stepwise manner with four batteries :

Primary test battery
based on the SHIRPA battery

Secondary test battery

Tertiary test battery
an acute observation in one or several pathologies

Fourth test battery
Bizarre and stereotyped behaviour
Urination / defecation
Stereotypies
Body position
Spontaneous activity
Respiration rate
Tremor
Behaviour in a new environment
Palpebral closure
Locomotor activity
Tail elevation
Touch escape
Startle response
Positional passivity
Body weight
General behaviour / reflexes
Visual placing
Grip strench
Body tone
Pinna reflex
Corneal reflex
Aggressivity
Convulsion
Righting reflex
Skin color
Locomotor activity
Open-field twice a day
Anxiety

Light / dark boxes
Depression
Forced swimming test : Porsolt's test
Memory

Object recognition test
Analgesia

Hot plate test
Anxiety
Open-field free exploratory test
Light / dark boxes
Open-field test
Elevated plus maze
Memory and learning
Object recognition test
Radial maze
T-maze
Schizophrenia
Hyperactivity test
Climbing test
Peripheral disorders
Electromyographical testing (EMG testing )
Motor-coordination tests (rotarod test, bar test ...)
Sensorimotor analysis (gait analysis , tail flick, hot plate )
Pharmacological analysis with reference coumpounds
Boulevard S. Brant
BIOPARC - 67 400
ILLKIRCH-FRANCE
Tel:
+33(0)388651606
Fax:
+33(0)388651622