ALLERGIC CONTACT DERMATITIS

  • Contact dermatitis is an adverse cutaneous reaction resulting from direct contact with an irritant or allergic substance.
    The skins reaction is an inflammation-driven process characterized by a swollen itchy red rash or rough and dry skin.


    • OVALBUMIN model

      Delayed Type Hypersensitivity is induced in female Lewis rats by a subcutaneous injection of an emulsion of ovalbumin/complete Freund's adjuvant. One week later, the rats are challenged with an injection of ovalbumin in the pinna ear.


    • OXAZOLONE model

      Oxazolone is an allergic contact dermatitis inducer resulting in a type I cytokine response.

  • OVALBUMIN model
    Delayed-Type Hypersensitivity (DTH) in Lewis rat



    Ear swelling induced by ovalbumin challenge is reduced by dexamethasone treatment

  • OXAZOLONE model
    Identification of anti-inflammatory / immuno-modulating drugs



    Ear swelling induced by oxazolone challenge in the rat. Dexamethasone treatment signficantly reduced the reaction.