for CNS and PNS disorders
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neurofit@neurofit.com
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Validated in vitro and in vivo disease and safety models for drug screening
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Therapeutic area
ADHD
ANIMAL model
Scopolamine
T-Maze
ALLERGIC CONTACT DERMATITIS
ANIMAL models
Ovalbumine
Oxazolone
ALZHEIMER'S DISEASE
ANIMAL models
Scopolamine
T-Maze
Passive avoidance
Novel Object Recognition
Aged mouse
T-Maze
Amyloid beta ( Aβ )
Passive avoidance
Methyllycaconitine
T-Maze
LPS-induced inflammation
T-Maze
CELLULAR models
Amyloid β intoxication (Aβ1-40/1-42)
Viability and survival tests
Basal Amyloid β production
Cortical neurons
Neurite outgrowth
iPSC-derived neurons
AMYOTROPHIC LATERAL SCLEROSIS
ANIMAL models
Measure of neuromuscular junction and nerve fiber morphometry
CELLULAR models
Glutamate and NMDA
Survival tests
Nerve / Muscle coculture
Innervated muscle fiber area
Innervation rate
(video samples)
Spinal motor neurons
Neurite outgrowth
ANXIETY
ANIMAL models
Panic anxiety
Cholecystokinin tetrapeptide (CCK-4)
Yohimbine
Spontaneous Paradigm
Light-Dark
Marble Burying
Elevated Plus Maze
DEPRESSION
ANIMAL models
Forced Swimming test
Marble Burying
CELLULAR models
Cortical neurons : neurite outgrowth
iPSC : neurite outgrowth
EPILEPSY
ANIMAL models
Pentylenetetrazol ( PTZ )
INFLAMMATION ( acute )
ANIMAL model
Carrageenan mouse air pouch
LPS-induced inflammation
CELLULAR models
Neuro-inflammation
MULTIPLE SCLEROSIS
ANIMAL models
RR-EAE
MBP-EAE
CELLULAR models
Oligodendrocyte Precursor Proliferation
NEUROPATHIC PAIN
ANIMAL models
Formalin
Acute pain
Tail Flick
Hot Plate
Paw pressure
PARKINSON'S DISEASE
ANIMAL models
6-OHDA (hemiparkinson)
Haldol (catalepsy)
CELLULAR models
MPP+ / 6-OHDA
Viability and survival tests
PERIPHERAL NEUROPATHIES
ANIMAL models
Sciatic Nerve Crush
Streptozotocin ( STZ )
Chemotherapy : IENF
CELLULAR models
Basal condition
Sensory neurons & Schwann cells
Purified sensory neurons culture
Adult DRG culture
Cisplatin
Sensory neurons & Schwann cells
Purified sensory neurons culture
Taxol
Sensory neurons & Schwann cells
Purified sensory neurons culture
Vincristine
Sensory neurons & Schwann cells
Purified sensory neurons culture
RHEUMATOID ARTHRITIS
ANIMAL models
Pristane
Collagen
SCHIZOPHRENIA
ANIMAL models
MK-801
T-Maze ( cognition )
Open-Field ( hyperactivity )
Phencyclidine
T-Maze ( cognition )
Open-Field ( hyperactivity )
D-amphetamine
Open-Field ( hyperactivity )
SIDE EFFECTS
ANIMAL models
Memory
Open-Field
Rotarod
Wire-Hanging
SPASTICITY
ANIMAL models
Hypertonia
TESTS
ANIMAL / BEHAVIORAL TESTS
COGNITION
T-Maze
Passive avoidance
Novel Object Recognition
ANXIETY / DEPRESSION
Marble Burying
Forced Swimming test
Elevated Plus Maze
Light-Dark test
PAIN / INFLAMMATION
Hot Plate
DWB
Paw pressure
Tail flick
SENSORI-MOTOR FUNCTION
Open-Field
Rotarod
DWB
Beam walking
Wire-Hanging
SIDE EFFECTS
Open-Field
Rotarod
Memory
Wire-Hanging
TOXICITY
ELECTROMYOGRAPHY (EMG)
NERVE FUNCTION: SNCV
NEUROMUSCULAR FUNCTION: CMAP
HISTOMORPHOMETRY
IENF
Myelin thickness (g-ratio)
Axon caliber / distribution
CELLULAR TESTS
COGNITION
Neurite outgrowth
Survival and Viability
Basal Amyloid β production
DEPRESSION
Neurite outgrowth
SPINAL CORD INJURY
Neurite outgrowth
Nerve / Muscle coculture
NEURO-INFLAMMATION
Survival and Biomarkers
EXCITOTOXICITY
iPSC-derived NEURONS
Scientific corner
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VALIDATION DATA
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